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1

Experiments with mixtures: Designs, models, and the analysis of mixture data. Second edition. By John A. Cornell. John Wiley: New York. 1990. xix + 631 pp. 16 × 23 cm. ISBN 0-471-52221-X. $59.95

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1991

Langue:

english

Fichier:

PDF, 150 KB

english, 1991

2

Usefulness of the Two-Compartment Open Model in Pharmacokinetics

Carl M. Metzler

Journal:

Journal of the American Statistical Association

Année:

1971

Langue:

english

Fichier:

PDF, 756 KB

english, 1971

3

Statistical methodology in the pharmaceutical sciences. Edited by D. S. Berry. Marcel Dekker: New York. 1990, viii + 578 pp. 16 × 23 cm. ISBN: 0-8247-8117-1. $125.00

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 150 KB

english, 1990

4

Effect of dog food containing 460 ppm fluoride on rat reproduction

Marks, Thomas A., Schellenberg, Diana, Metzler, Carl M., Oostveen, Jo, Morey, Mary Jane

Journal:

Journal of Toxicology and Environmental Health

Année:

1984

Langue:

english

Fichier:

PDF, 405 KB

english, 1984

5

Multiclinic Double-Blind Comparison of Triazolam and Flurazepam for Seven Nights in Outpatients with Insomnia

FABRE, LOUIS P., GROSS, LUDWIG, PASIGAJEN, VICTORIOSA, METZLER, CARL

Journal:

Journal of Clinical Pharmacology

Année:

1977

Langue:

english

Fichier:

PDF, 887 KB

english, 1977

6

Mammalian cell transformation and aneuploidy induced by five bisphenols

Takeki Tsutsui, Yukiko Tamura, Ayako Suzuki, Yutaka Hirose, Morio Kobayashi, Hiroyuki Nishimura, Manfred Metzler, J. Carl Barrett

Journal:

International Journal of Cancer

Année:

2000

Langue:

english

Fichier:

PDF, 75 KB

english, 2000

7

Cell-transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalian cells

Takeki Tsutsui, Yukiko Tamura, Eiichi Yagi, Hitomi Someya, Itsuro Hori, Manfred Metzler, J. Carl Barrett

Journal:

International Journal of Cancer

Année:

2003

Langue:

english

Fichier:

PDF, 202 KB

english, 2003

8

Cell-transforming activity and estrogenicity of bisphenol-A and 4 of its analogs in mammalian cells

Hideaki Kanai, J. Carl Barrett, Manfred Metzler, Takeki Tsutsui

Journal:

International Journal of Cancer

Année:

2001

Langue:

english

Fichier:

PDF, 139 KB

english, 2001

9

Estimation of rate constants for absorption and elimination from blood concentration data

John G. Wagner, Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1967

Langue:

english

Fichier:

PDF, 166 KB

english, 1967

10

Prediction of blood levels after multiple doses from single-dose blood level data: Data generated with two-compartment open model analyzed according to the one-compartment open model

John G. Wagner, Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1969

Langue:

english

Fichier:

PDF, 667 KB

english, 1969

11

Clindamycin dose-bioavailability relationships

Carl M. Metzler, Ray Dehaan, Diana Schellenberg, William D. Vandenbosch

Journal:

Journal of Pharmaceutical Sciences

Année:

1973

Langue:

english

Fichier:

PDF, 815 KB

english, 1973

12

Computational problems of compartment models with michaelis-menten-type elimination

Carl M. Metzler, D. D. M. Tong

Journal:

Journal of Pharmaceutical Sciences

Année:

1981

Langue:

english

Fichier:

PDF, 608 KB

english, 1981

13

Extended hildebrand solubility approach: Testosterone and testosterone propionate in binary solvents

A. Martin, P. L. Wu, A. Adjei, M. Mehdizadeh, K. C. James, Carl Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1982

Langue:

english

Fichier:

PDF, 831 KB

english, 1982

14

Extended least squares (ELS) for pharmacokinetic models

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1987

Langue:

english

Fichier:

PDF, 705 KB

english, 1987

15

Response to “Commentary on ‘Extended least squares (ELS) for pharmacokinetic models’”

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1988

Langue:

english

Fichier:

PDF, 58 KB

english, 1988

16

Biopharmaceutical statistics for drug development. Statistics: Textbooks and Monographs Series, Volume 86. Edited by K. E. Peace. Marcel Dekker: New York. 1988. xii + 640 pp. 17 × 25 cm. ISBN 0-8247-7798-0. $125.00

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1988

Langue:

english

Fichier:

PDF, 161 KB

english, 1988

17

Statistical reliability theory. By I. B. Gertsbakh. Marcel Dekker: New York. 1989. xii + 331 pp. 16 × 23 cm. ISBN ISBN 0-8247-8019-1. $94.75

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 155 KB

english, 1990

18

Pharmaceutical statistics: Practical and clinical applications. Second edition. By Sanford Bolton. Marcel Dekker: New York. 1990. xvii + 646 pp. 16 × 23 cm. ISBN 0-8247-8267-4, $ 99.75

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1991

Langue:

english

Fichier:

PDF, 122 KB

english, 1991

19

Statistical Issues in Drug Research and Development. Edited by Karl E. Peace. Marcel Dekker: New York. 1990. xi + 366 pp. 16 × 23 cm. ISBN 0-8247-8290-9. $99.75

Carl M. Metzler

Journal:

Journal of Pharmaceutical Sciences

Année:

1991

Langue:

english

Fichier:

PDF, 141 KB

english, 1991

20

Non-peptide αvβ3 antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl β-amino acids as aspartic acid replacements

Karen M Brashear, Cecilia A Hunt, Brian T Kucer, Mark E Duggan, George D Hartman, Gideon A Rodan, Sevgi B Rodan, Chi-Tai Leu, Thomayant Prueksaritanont, Carmen Fernandez-Metzler, Andrea Barrish, Carl

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 120 KB

english, 2002

21

Sample sizes for bioequivalence studies

Carl M. Metzler

Journal:

Statistics in Medicine

Année:

1991

Langue:

english

Fichier:

PDF, 543 KB

english, 1991

22

Pharmacokinetics and pharmacodynamics of oral diazepam: Effect of dose, plasma concentration, and time

Friedman, H, Greenblatt, David J, Peters, Gary R, Metzler, Carl M, Charlton, Melody D, Harmatz, Jerold S, Antal, Edward J, Sanborn, Elmer C, Francom, Steven F

Journal:

Clinical Pharmacology & Therapeutics

Année:

1992

Langue:

english

Fichier:

PDF, 680 KB

english, 1992

23

Clindamycin bioavailability from clindamycin-2-palmitate and clindamycin-2-hexadecylcarbonate in man

Arlington A. Forist, Ray M. DeHaan, Carl M. Metzler

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1973

Langue:

english

Fichier:

PDF, 467 KB

english, 1973

24

The efficient use of NONLIN for unbalanced multiple dose data

Gary L. Elfring, Carl M. Metzler

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1981

Langue:

english

Fichier:

PDF, 233 KB

english, 1981

25

Commentary to “linear and nonlinear system approaches in pharmacokinetics. How much do they have to offer? II. The response mapping operator (RMO) approach”

Carl M. Metzler

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1988

Langue:

english

Fichier:

PDF, 340 KB

english, 1988

26

Linear and nonlinear system approaches in pharmacokinetics: How much do they have to offer? II. The response mapping operator (RMO) approach

Peter Veng-Pedersen, Ronald A. Siegel, Harold Boxenbaum, Carl M. Metzler

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1988

Langue:

english

Fichier:

PDF, 1.06 MB

english, 1988

27

Curve fitting and modeling in pharmacokinetics: A response

Carl M. Metzler, Gary L. Elfring

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1978

Langue:

english

Fichier:

PDF, 235 KB

english, 1978

28

Assessment of Variance in Bioavailability Studies: Comments on the Article by McNamaraet al.

Carl M. Metzler

Journal:

Pharmaceutical Research

Année:

1987

Fichier:

PDF, 154 KB

1987

29

A computer study of sampling plans for blood level studies in children

Carl M. Metzler, Ray M. Dehaan

Journal:

Computers in Biology and Medicine

Année:

1972

Langue:

english

Fichier:

PDF, 559 KB

english, 1972

30

Estimation of pharmacokinetic parameters: Statistical considerations

Carl M. Metzler

Journal:

Pharmacology & Therapeutics

Année:

1981

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1981

31

Effects of a fish oil concentrate in patients with hypercholesterolemia

Donald M. Demke, Gary R. Peters, Otto I. Linet, Carl M. Metzler, Karen A. Klott

Journal:

Atherosclerosis

Année:

1988

Langue:

english

Fichier:

PDF, 760 KB

english, 1988

32

Effect of H2 blockade in the challenged allergic nose

Brooks, Carter D., Butler, Diane, Metzler, Carl

Journal:

Journal of Allergy and Clinical Immunology

Année:

1982

Langue:

english

Fichier:

PDF, 400 KB

english, 1982

33

Usefulness of the Two-Compartment Open Model in Pharmacokinetics

Metzler, Carl M.

Journal:

Journal of the American Statistical Association

Année:

1971

Langue:

english

Fichier:

PDF, 434 KB

english, 1971

34

Pharmacokinetic Studies of Clindamycin Phosphate

DeHAAN, RAY M., METZLER, CARL M., SCHELLENBERG, DIANA, VANDENBOSCH, WILLIAM D.

Journal:

The Journal of Clinical Pharmacology and New Drugs

Année:

1973

Langue:

english

Fichier:

PDF, 1.96 MB

english, 1973

35

Rapid Endovascular Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction

Erlinge, David, Götberg, Matthias, Lang, Irene, Holzer, Michael, Noc, Marko, Clemmensen, Peter, Jensen, Ulf, Metzler, Bernhard, James, Stefan, Bötker, Hans Erik, Omerovic, Elmir, Engblom, Henrik, Carl

Journal:

Journal of the American College of Cardiology

Année:

2014

Langue:

english

Fichier:

PDF, 673 KB

english, 2014

36

Ciprostene in patients with peripheral vascular disease (PVD). An open-label, tolerance trial

Linet, Otto I., Luderer, Jack R., Froeschke, Monica, Welch, Susan, Metzler, Carl M., Eckert, Susan M.

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Année:

1988

Langue:

english

Fichier:

PDF, 557 KB

english, 1988

37

Usefulness of the Two-Compartment Open Model in Pharmacokinetics: Rejoinder

Carl M. Metzler

Journal:

Journal of the American Statistical Association

Année:

1971

Langue:

english

Fichier:

PDF, 189 KB

english, 1971

38

Bioavailability -- A Problem in Equivalence

Metzler, Carl M.

Journal:

Année:

1974

Langue:

english

Fichier:

PDF, 912 KB

english, 1974

39

Phosphine photolabilisation studies of (η5-C5H5)Fe(PPh3)(CO)COR (R = Me, Ph, 2,6-C6H3F2) and (η5-C5Me5)Fe(PPh3)(CO)COR (R = Me, 2,6-C6H3F2) utilising NMR, laser desorption FT ICR MS and photofragmentation voltammetry analysis

Aplin, Robin T., Booth, Jonathan, Compton, Richard G., Davies, Stephen G., Jones, Simon, McNally, John P., Metzler, Michael R., Watkins, W. Carl

Journal:

Journal of the Chemical Society Perkin Transactions 2

Année:

1999

Langue:

english

Fichier:

PDF, 350 KB

english, 1999

40

Photolabilisation of phosphine ligands bound to iron: photofragmentation voltammetry analysis

Davies, Stephen G., Metzler, Michael R., Watkins, W. Carl, Compton, Richard G., Booth, Jonathan, Eklund, John C.

Journal:

Journal of the Chemical Society Perkin Transactions 2

Année:

1993

Langue:

english

Fichier:

PDF, 350 KB

english, 1993

41

Photofragmentation voltammetry studies of the aminocarbene complexes [(?5-C5H5)Fe(CO)(L){?C(NHR1)(R2)}]BF4[L = PPh3, P(p-Tol)3; R1= Me, CH2Ph; R2= Me, Bu]

Davies, Stephen G., Metzler, Michael R., Watkins, W. Carl, Compton, Richard G., Booth, Jonathan, Eklund, John C.

Journal:

Journal of the Chemical Society Perkin Transactions 2

Année:

1993

Langue:

english

Fichier:

PDF, 806 KB

english, 1993

42

A computer study of nonlinear standard curves in chemical and biological assays

Metzler, Carl M., Elfring, Gary L.

Journal:

Journal of Statistical Computation and Simulation

Année:

1972

Langue:

english

Fichier:

PDF, 379 KB

english, 1972

43

Bioavailability/Bioequivalence: Study Design and Statistical Issues

Metzler, Carl M.

Journal:

Journal of Clinical Pharmacology

Année:

1989

Langue:

english

Fichier:

PDF, 604 KB

english, 1989

44

Rejoinder

Metzler, Carl M.

Journal:

Journal of the American Statistical Association

Année:

1971

Langue:

english

Fichier:

PDF, 131 KB

english, 1971

45

Continuous Intravenous Dosing with Ciprostene Using a Portable Pump in Ambulatory Patients

Wolf, Daniel L., Metzler, Carl M., Froeschke, Monica O., Luderer, Jack R.

Journal:

Journal of Clinical Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 680 KB

english, 1993

46

Attenuation of Protection With Repeated Cromolyn Dosing Before Exercise Challenge in Subjects With Asthma

Brooks, Carter D., Nelson, Amy L., Metzler, Carl

Journal:

Journal of Clinical Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 919 KB

english, 1986

47

Clindamycin Serum Concentrations After Administration of Clindamycin Palmitate With Food

de HAAN, RAY M., BOSCH, WILLIAM D. VANDEN, METZLER, CARL M.

Journal:

The Journal of Clinical Pharmacology and New Drugs

Année:

1972

Langue:

english

Fichier:

PDF, 848 KB

english, 1972

48

The Effect of Itazigrel and Aspirin on the Mucosa of the Esophagus, Stomach, and Duodenum of Normal Subjects

Demke, Donald M., Luderer, John R., Wakefield, Linda K., Euler, Arthur R., Brouwer, Robert D., Metzler, Carl M.

Journal:

Journal of Clinical Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 815 KB

english, 1987

49

A mathematical model for the pharmacokinetics of LSD effect

Metzler, Carl M., Levy, Gerhard, Mainland, Donald

Journal:

Clinical Pharmacology & Therapeutics

Année:

1969

Langue:

english

Fichier:

PDF, 409 KB

english, 1969

50

DOSE-RELATED HEPATIC BLOOD FLOW EFFECTS DIFFERENTIATE NICORANDIL, HYDRALAZINE, AND ISOSORBIDE DINITRATE IN HEALTHY SUBJECTS

Wolf, Daniel L., Metzler, Carl M., Froeschke, Monica O., Luderer, John R.

Journal:

American Journal of Therapeutics

Année:

1994

Fichier:

PDF, 541 KB

1994